By Dr Harvey Risch
As of Wednesday, some 165,000 people in the United States have died from COVID-19. I have made the case in the American Journal of Epidemiology and in Newsweek that people who have a medical need to be treated can be treated early and successfully with hydroxychloroquine, zinc, and antibiotics such as azithromycin or doxycycline. I have also argued that these drugs are safe and have made that case privately to the Food and Drug Administration.
The pushback has been furious. Dr. Anthony Fauci has implied that I am incompetent, notwithstanding my hundreds of highly regarded, methodologically relevant publications in peer-reviewed scientific literature. A group of my Yale colleagues has publicly intimated that I am a zealot who is perpetrating a dangerous hoax and conspiracy theory. I have been attacked in news articles by journalists who, ignorant of the full picture, have spun hit pieces from cherry-picked sources.
These personal attacks are a dangerous distraction from the real issue of hydroxychloroquine’s effectiveness, which is solidly grounded in both substantial evidence and appropriate medical decision-making logic. Much of the evidence is presented in my articles.
To date, there are no studies whatsoever, published or in pre-print, that provide scientific evidence against the treatment approach for high-risk outpatients that I have described. None. Assertions to the contrary, whether by Fauci, the FDA, or anyone else, are without foundation. They constitute misleading and toxic disinformation.
What do you need to know to evaluate these smears against hydroxychloroquine? The first thing to understand is that COVID-19 has two main stages. At the first stage, it is a flu-like illness. That illness will not kill you. If you are a high-risk patient and begin treatment immediately, you will almost certainly be done with it in a few days. When not treated, high-risk patients may progress. The virus then causes severe pneumonia and attacks many organs, including the heart. In this second stage, hydroxychloroquine is not effective.
So, if you are told that hydroxychloroquine doesn’t work, ask this question: In which patients? Does it not work in those who have just started to have symptoms, or those sick enough to require hospitalization?
The second thing to know is that most low-risk patients survive without treatment. Low risk means you are under age 60 and have no chronic conditions such as diabetes, obesity, and hypertension, have no past treatment for cancer, are not immunocompromised, etc. High risk means you are over 60 or you have one or more of those chronic conditions. High-risk patients need immediate treatment when they first show symptoms. One should not wait for the COVID-19 test result, which can take days and can be wrong. Again, when Fauci and others say that randomized controlled trials show no benefit for hydroxychloroquine, you must ask: In which group of patients?
Every randomized controlled trial to date that has looked at early outpatient treatment has involved low-risk patients, patients who are not generally treated. In these studies, so few untreated control patients have required hospitalization that significant differences were not found. There has been only one exception: In a study done in Spain with low-risk patients, a small number of high-risk nursing home patients were included. For those patients, the medications cut the risk of a bad outcome in half.
I reiterate: If doctors, including any of my Yale colleagues, tell you that scientific data show that hydroxychloroquine does not work in outpatients, they are revealing that they can’t tell the difference between low-risk patients who are not generally treated and high-risk patients who need to be treated as quickly as possible. Doctors who do not understand this difference should not be treating COVID-19 patients.
What about medication safety? On July 1, the FDA posted a “black-letter warning” cautioning against using hydroxychloroquine “outside of the hospital setting,” meaning in outpatients. But on its website just below this warning, the FDA stated that the warning was based on data from hospitalized patients. To generalize and compare severely ill patients with COVID-induced pneumonia and possibly heart problems to outpatients is entirely improper.
In fact, the FDA has no information about adverse events in early outpatient use of hydroxychloroquine. The only available systematic information about adverse events among outpatients is discussed in my article in the American Journal of Epidemiology, where I show that hydroxychloroquine has been extremely safe in more than a million users.
It is a serious and unconscionable mistake that the FDA has used inpatient data to block emergency use petitions for outpatient use. Further, already back in March, the FDA approved the emergency use of hydroxychloroquine for hospitalized patients, for whom it is demonstrably less effective than for outpatients. If hydroxychloroquine satisfied the FDA criteria for emergency inpatient use in March, it should more than satisfy those criteria now for outpatient use, where the evidence is much stronger.
I can only speculate about the cause of the FDA’s recalcitrance. Hydroxychloroquine is an inexpensive, generic medication. Unlike certain profit-generating, patented medications, which have been promiscuously touted on the slimmest of evidence, hydroxychloroquine has no natural financial constituency. No one will get rich from it.
Further, it seems quite possible that the FDA, a third of whose funding comes from drug companies, is under intense pressure from those companies to be extremely conservative in its handling of hydroxychloroquine. If hydroxychloroquine is used widely and comes to be recognized as highly effective, the markets for expensive and patented COVID-19 medications, including intravenous drugs that can only be used in the hospital, will shrink substantially.
Whatever the reason for the FDA’s stonewalling on hydroxychloroquine, this much is certain: Americans are dying unnecessarily, the economy is in disarray, and the threads that bind our society together have frayed. I am speaking out, but where is everyone else? Where are our elected officials, including those who are themselves physicians? Some, including Rep. Andy Biggs of Arizona, have been discussing evidence of the drug’s effectiveness, but where are the rest?
This issue should not be a partisan one. If our elected officials are not willing to pry open the FDA, we must elect new officials. Why are we silent? The time to speak is now.
Harvey Risch, M.D., Ph.D., is a professor of epidemiology at Yale School of Public Health.
Letter to the Editor
Summation of Virologist Dr Judy Mikovits interview
Dr. Judy Mikovitis: COVID-19 has probably been in all flu vaccines since 2013/2015 Video
Dr. Mikovitis, former virologist at the U.S. Biological Warfare Lab, explains some startling truths:
Wearing a mask will make you sicker by forcing you to re-breathe the bacteria and viruses already in your respiratory system.
COVID-19 strain used in winter flu vaccines throughout the world since 2013
No test for COVID-19 is worthy of credence without at least another confirmatory results by a different kind of test
The only criteria for immunity is having the antibodies.
Never accept the COVID-19 vaccine.
You cannot catch a virus from coughing, it live no more than 1 hour on surfaces.
COVID-19 is not lethal enough to cause any more than 0.8% of those infected seriously sick.
The Pandemic is a complete hoax being used to enslave humanity.
All vaccines will make some of those who receive them sick with the disease against which it was developed to prevent.
COVID-19 does not come from animal to human transfer, it was grown in a lab.
Winter flu vaccines is the only plausible explanation for world wide spread of COVID-19.
Being infected does not mean you are sick or infectious to others.
Symptoms are not a scientific way of diagnosing COVID-19.
Dr. Anthony Fauci has intervened to cover up study which proved that vaccinations cause cancer and other cancer causing viruses, in addition to Autism.
Polio vaccines transmitted cancer causing SIV & Sv40 virus.
The immunity granted by the U.S. Government in 1986 at the insistence of Dr. Anthony Fauci, to Vaccine manufacturers has made them dangerous, dirty and unsafe.
Every vaccine can cause in some persons a lethal immune response which can kill them.
The FDA is a criminal organization.
Korea responded by using the correct tests.
The USA is suffering from a plague of corruption in the Vaccine industry.
Vaccine Industry is systematically ending the production of safer medicines which would cure or prevent infection, because there is no money in preventing and curing disease.
Vaccinations. .. The Shot in the DARK – Documentary
January 5, 2020
from Kev at Crisscross